Pharmacologically active substances of microbial origin. .ALPHA.-Glucosidase inhibitor.
نویسندگان
چکیده
منابع مشابه
Voglibose: An Alpha Glucosidase Inhibitor
keywords: Postprandial hyperglycaemia (PPHG), Alpha glucosidase inhibitors (αGI) ABSTRACT Diabetes Mellitus (DM) is a morbid disease worldwide, with increasing incidence as time passes. It has macro-vascular and micro-vascular complications. The main cause of these complications is poorly controlled postprandial hyperglycaemia. Alpha glucosidase inhibitors, namely acarbose, voglibose and miglit...
متن کاملVoglibose, an Alpha-glucosidase Inhibitor, to Increase Active Glucagon-like Peptide-1 Levels
Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in patients with diabetes mellitus. Voglibose is known for its ability to increase glucagon-like peptide-1 (GLP-1) secretion in humans. Our recent study demonstrated new mechanisms by which voglibose increases plasma active GLP-1 levels in diabetic ob/ob mice. As expected, the stimulatory effects of...
متن کاملModification of 15-akylidene andrographolide derivatives as alpha-glucosidase inhibitor.
15-Alkylidene andrographolide derivatives were specific alpha-glucosidase inhibitors. Semi-synthetic studies of these derivatives led to new alpha-glucosidase inhibitors. Their alpha-glucosidase inhibitory activity was evaluated. Bioactivity results indicated that most of the derivatives were excellent alpha-glucosidase inhibitors. Among them, 6c displayed the best alpha-glucosidase inhibitory ...
متن کاملSelective Antibiotic Action of Various Substances of Microbial Origin.
Since Pasteur first demonstrated that certain micro6rganisms are able to exert antagonistic or antibiotic effects upon other organisms, an extensive literature has accumulated (Waksman, 1941). The presence of living organisms is often necessary for the phenomenon of antagonism to take place. In many cases, the antagonist was found to produce an active substance responsible for this action. The ...
متن کاملA potent alpha-glucosidase inhibitor from Myristica cinnamomea King.
A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plo...
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ژورنال
عنوان ژورنال: Journal of the agricultural chemical society of Japan
سال: 1989
ISSN: 0002-1407,1883-6844
DOI: 10.1271/nogeikagaku1924.63.217